The ACE2 Polyclonal Antibody (PAC064123) is a valuable tool for researchers studying angiotensin-converting enzyme 2 (ACE2), a crucial enzyme involved in the renin-angiotensin system and known for its role in cardiovascular and respiratory diseases, including COVID-19. This antibody, derived from rabbit serum, demonstrates high specificity and sensitivity for human samples, making it ideal for use in various research applications such as Western blot analysis.ACE2 is a key regulator of blood pressure and fluid balance, and its dysregulation has been associated with various cardiovascular and respiratory disorders. Additionally, the interaction between ACE2 and the spike protein of SARS-CoV-2 has brought immense attention to ACE2 as a potential therapeutic target for COVID-19.
This antibody allows for the detection and analysis of ACE2 protein levels in different cell types, providing valuable insights for studies in cardiology, pulmonology, and infectious diseases.By understanding the expression and activity of ACE2, researchers can uncover potential therapeutic strategies for treating cardiovascular diseases, respiratory conditions, and viral infections. The ACE2 Polyclonal Antibody (PAC064123) serves as a reliable tool for investigating the functions and mechanisms of ACE2 in health and disease, ultimately contributing to the development of novel treatments and interventions in the medical field.
Antibody Name:
Ace2 Antibody (PACO64123)
Antibody SKU:
PACO64123
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:1000-1:5000
Species Reactivity:
Rat
Immunogen:
Peptide sequence from Rat Ace2 protein (105-118AA)
Western Blot. Positive WB detected in: Rat Spleen tissue, Rat Kidney tissue. All lanes: Ace2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 93 kDa. Observed band size: 93 kDa.
Background:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. Plays an important role in amino acid, transport by acting as binding partner of amino acid, transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity (By similarity).
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.
NCBI Summary:
enzyme peptidyl-dipeptidase; mouse homolog has a role in regulation of cardiac contractility and regulating Angiotensin 1 and 2 levels [RGD, Feb 2006]
