The ACE Polyclonal Antibody (CAB2805) is a valuable tool for researchers studying ACE, a key enzyme involved in the renin-angiotensin system, which plays a crucial role in regulating blood pressure and fluid balance. This antibody is produced in rabbits and has been validated for use in Western blot applications with high reactivity towards human samples.ACE, also known as angiotensin-converting enzyme, is a critical player in the control of blood pressure and is a target for medications used to treat hypertension and heart failure.
Understanding the regulation and function of ACE is essential for developing new therapeutic strategies for cardiovascular diseases.By specifically binding to the ACE protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in cardiovascular physiology and pharmacology. With its ability to target ACE, researchers can gain insights into the enzyme's role in health and disease, paving the way for the development of novel treatments for cardiovascular disorders.
Product Name:
ACE1 Rabbit Polyclonal Antibody
SKU:
CAB2805
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 554-758 of human ACE11 (NP_000780.1).
Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein.
Calculated MW:
150kDa
Observed MW:
170kDa
This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms.
Purification Method:
Affinity purification
Gene ID:
1636
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACE1 Rabbit pAb (CAB2805) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
