The ACD Polyclonal Antibody (CAB12177) is a crucial tool for researchers studying ACD, an essential component involved in telomere maintenance and DNA replication. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ACD protein, this antibody enables accurate detection and analysis in various research settings, making it ideal for investigations into telomere biology, cancer research, and aging-related studies.
ACD, also known as TPP1, is a key player in telomere protection and length regulation, making it a critical factor in cellular senescence and genomic stability. Dysregulation of ACD has been implicated in various diseases, including cancer and premature aging syndromes, highlighting its importance in understanding cellular aging mechanisms and disease pathogenesis. The ACD Polyclonal Antibody provides researchers with a valuable tool to delve deeper into the functions of ACD and its implications in health and disease.
Product Name:
ACD Rabbit Polyclonal Antibody
SKU:
CAB12177
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1).
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
Purification Method:
Affinity purification
Gene ID:
65057
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and ACD knockdown (KD) 293T(KD) cells, using ACD Rabbit pAb (CAB12177) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
