The ACAT2 Polyclonal Antibody (CAB7866) is a vital tool for researchers studying ACAT2, an enzyme involved in cholesterol metabolism and the formation of lipoproteins. This antibody is produced through immunization of rabbits and has high specificity for human samples, making it ideal for studies focusing on cholesterol homeostasis and lipid metabolism. ACAT2 is primarily found in the liver and intestine, where it plays a crucial role in the synthesis of cholesterol esters. Dysregulation of ACAT2 activity has been linked to various metabolic disorders, including atherosclerosis and non-alcoholic fatty liver disease.
By targeting ACAT2 with this antibody, researchers can effectively study the enzyme's function and its potential as a therapeutic target for metabolic diseases.With its validated performance in Western blot applications, the ACAT2 Polyclonal Antibody (CAB7866) enables precise detection and analysis of ACAT2 protein levels in different cell types and tissues. This antibody is a valuable resource for advancing our understanding of cholesterol metabolism and developing novel strategies for treating metabolic disorders associated with dyslipidemia.
Product Name:
ACAT2 Rabbit Polyclonal Antibody
SKU:
CAB7866
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 159-277 of human ACAT2 (NP_005882.2).
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
39
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACAT2 Rabbit pAb (CAB7866) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
