The ACAN Polyclonal Antibody (CAB8536) is specifically designed for research involving ACAN, a key component of the extracellular matrix in cartilage tissues. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in applications such as Western blot and immunohistochemistry.ACAN, also known as aggrecan, is essential for maintaining the structure and function of cartilage in the body. It plays a crucial role in supporting joint health and mobility, making it a valuable target for studies related to musculoskeletal disorders such as osteoarthritis.
By detecting and analyzing ACAN protein levels in various cell types, this antibody is ideal for research in orthopedics, rheumatology, and regenerative medicine.Understanding the role of ACAN in cartilage biology is fundamental for developing treatments and interventions that can promote cartilage repair and regeneration. The use of the ACAN Polyclonal Antibody in research can provide valuable insights into the mechanisms underlying cartilage degradation and potential therapeutic strategies for conditions affecting joint health.
Product Name:
Aggrecan Rabbit Polyclonal Antibody
SKU:
CAB8536
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-575 of human Aggrecan (NP_037359.3).
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Purification Method:
Affinity purification
Gene ID:
176
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Mouse cartilage using Aggrecan Rabbit pAb (CAB8536) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
