The ACAD8 Polyclonal Antibody is a valuable tool for researchers studying ACAD8, a critical enzyme involved in fatty acid metabolism and energy production within the mitochondria. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting ACAD8 protein levels in human samples, making it suitable for use in Western blot applications.ACAD8 plays a crucial role in the catabolism of fatty acids, particularly in the beta oxidation process, which is essential for generating ATP and maintaining cellular energy homeostasis. Dysregulation of ACAD8 activity has been linked to various metabolic disorders, highlighting its importance in metabolic function and overall health.
By utilizing the ACAD8 Polyclonal Antibody, researchers can investigate the expression and localization of ACAD8 in different cell types and tissues, providing valuable insights into its physiological function and potential implications in metabolic diseases. This antibody serves as a valuable tool for advancing research in metabolic pathways and identifying potential therapeutic targets for metabolic disorders.
Western Blot. Positive WB detected in: Mouse liver tissue, Mouse heart tissue, Mouse skeletal muscle tissue. All lanes: ACAD8 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46, 32, 39 kDa. Observed band size: 46, 39 kDa.
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO42554 at dilution of 1:100.
Background:
Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
Synonyms:
Isobutyryl-CoA dehydrogenase, mitochondrial (EC 1.3.99.-) (Activator-recruited cofactor 42 kDa component) (ARC42) (Acyl-CoA dehydrogenase family member 8) (ACAD-8), ACAD8, ARC42 IBD
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]
