The ACAD10 Polyclonal Antibody (PAC015246) is specifically designed for researchers studying ACAD10, a key enzyme involved in fatty acid metabolism. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the ACAD10 protein, researchers can easily detect and analyze its expression in various cell types, making it an essential tool for studies in metabolism, lipid metabolism disorders, and other related fields.ACAD10 is a critical enzyme that plays a pivotal role in fatty acid oxidation and energy production within the mitochondria.
Dysregulation of ACAD10 activity has been linked to metabolic disorders such as fatty acid oxidation disorders and mitochondrial dysfunction. By studying the function and expression of ACAD10, researchers can gain insight into these conditions and potentially develop new therapeutic approaches.Overall, the ACAD10 Polyclonal Antibody is a valuable asset for researchers looking to explore the role of ACAD10 in cellular metabolism and related diseases. Its high specificity and sensitivity make it an ideal tool for furthering our understanding of fatty acid metabolism and its implications in health and disease.
Antibody Name:
ACAD10 Antibody (PACO15246)
Antibody SKU:
PACO15246
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human ACAD10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15246(ACAD10 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15246(ACAD10 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acid, in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Synonyms:
acyl-CoA dehydrogenase family, member 10
UniProt Protein Function:
ACAD10: Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA. Belongs to the acyl-CoA dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.99.-; Mitochondrial; OxidoreductaseChromosomal Location of Human Ortholog: 12q24.12Cellular Component: mitochondrionMolecular Function: acyl-CoA dehydrogenase activity; FAD binding; hydrolase activity; transferase activity, transferring phosphorus-containing groups
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
