The ACAD10 Antibody (PAC015245) is a highly specific tool for research involving the ACAD10 protein, a key enzyme involved in fatty acid metabolism. This antibody, produced in rabbits, has been validated for its high reactivity with human samples and is suitable for use in Western blot applications. By binding to the ACAD10 protein, this antibody allows for the detection and analysis of ACAD10 in various cell types, making it an excellent choice for studies in metabolism and related diseases.ACAD10 plays a vital role in fatty acid beta-oxidation, a process essential for energy production and lipid metabolism.
Dysregulation of ACAD10 activity has been linked to metabolic disorders such as obesity, diabetes, and fatty liver disease. Therefore, understanding the function of ACAD10 is crucial for developing interventions to treat or prevent these conditions.The ACAD10 Antibody is a valuable tool for researchers investigating the role of ACAD10 in metabolic pathways and its potential implications for human health. Its specificity and reliability make it an excellent choice for studies aiming to unravel the complex mechanisms underlying metabolic diseases.
Antibody Name:
ACAD10 Antibody (PACO15245)
Antibody SKU:
PACO15245
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human ACAD10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15245(ACAD10 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15245(ACAD10 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acid, in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Synonyms:
acyl-CoA dehydrogenase family, member 10
UniProt Protein Function:
ACAD10: Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA. Belongs to the acyl-CoA dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.99.-; Mitochondrial; OxidoreductaseChromosomal Location of Human Ortholog: 12q24.12Cellular Component: mitochondrionMolecular Function: acyl-CoA dehydrogenase activity; FAD binding; hydrolase activity; transferase activity, transferring phosphorus-containing groups
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
