The ACACA Polyclonal Antibody (CAB15606) is a valuable tool for researchers studying ACACA, an enzyme involved in lipid metabolism and energy production. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ACACA protein, this antibody allows for the precise detection and analysis of ACACA in a variety of cell types, making it an essential component for studies in metabolism and related research areas.ACACA, also known as acetyl-CoA carboxylase alpha, plays a crucial role in fatty acid synthesis and energy regulation.
Dysregulation of ACACA has been linked to various metabolic disorders, making it a key target for research into obesity, diabetes, and other metabolic diseases. Understanding the function and regulation of ACACA is essential for developing targeted therapies and interventions to address these conditions.Overall, the ACACA Polyclonal Antibody (CAB15606) provides researchers with a reliable tool for studying the role of ACACA in metabolism and related pathways, offering insights that could lead to new treatment approaches for metabolic disorders and related conditions.
Product Name:
acetyl-ACC1 Rabbit Polyclonal Antibody
SKU:
CAB15606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2266-2346 of human ACC1 (NP_942133.1).
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
31
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACC1 Rabbit pAb (CAB15606) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
