| UniProt Protein Function: | abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-bindingChromosomal Location of Human Ortholog: 10q25Cellular Component: lamellipodium; cytoplasm; stress fiber; actin cytoskeletonMolecular Function: protein binding; zinc ion binding; actin bindingBiological Process: lamellipodium biogenesis; axon guidance; organ morphogenesis; visual perception; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cytoskeleton organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14639 |
| NCBI GenInfo Identifier: | 206729924 |
| NCBI Gene ID: | 3983 |
| NCBI Accession: | O14639.3 |
| UniProt Secondary Accession: | O14639,Q15039, Q5JVV1, Q5JVV2, Q5T6N3, Q5T6N5, Q68CQ9 Q9BUP1, A6NI16, A6NJ06 |
| UniProt Related Accession: | O14639 |
| Molecular Weight: | 52,056 Da |
| NCBI Full Name: | Actin-binding LIM protein 1 |
| NCBI Synonym Full Names: | actin binding LIM protein 1 |
| NCBI Official Symbol: | ABLIM1Â Â |
| NCBI Official Synonym Symbols: | ABLIM; LIMAB1; LIMATIN; abLIM-1Â Â |
| NCBI Protein Information: | actin-binding LIM protein 1; actin-binding double-zinc-finger protein; actin-binding LIM protein family member 1 |
| UniProt Protein Name: | Actin-binding LIM protein 1 |
| UniProt Synonym Protein Names: | Actin-binding LIM protein family member 1; Actin-binding double zinc finger protein; LIMAB1; Limatin |
| Protein Family: | Actin-binding LIM protein |
| UniProt Gene Name: | ABLIM1Â Â |
| UniProt Entry Name: | ABLM1_HUMAN |
