The ABLIM1 Antibody (PAC015240) is a valuable tool for researchers studying ABLIM1, a protein that plays a key role in cell morphology and cytoskeletal organization. This polyclonal antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for a variety of research applications.ABLIM1 is involved in cell shape regulation and actin cytoskeleton dynamics, making it important for processes such as cell migration, adhesion, and signaling. The ABLIM1 Antibody binds specifically to the ABLIM1 protein, allowing for accurate detection and analysis in different cell types and tissues.
Researchers in cell biology, developmental biology, and cancer research can benefit from using the ABLIM1 Antibody to study the function and regulation of ABLIM1 in various cellular processes. By gaining a better understanding of ABLIM1 function, researchers can uncover new insights into cell behavior and potentially identify novel therapeutic targets for conditions related to cell morphology and cytoskeletal dynamics.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15240(ABLIM1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO15240(ABLIM1 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15240(ABLIM1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms:
Actin binding LIM protein 1
UniProt Protein Function:
abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-bindingChromosomal Location of Human Ortholog: 10q25Cellular Component: lamellipodium; cytoplasm; stress fiber; actin cytoskeletonMolecular Function: protein binding; zinc ion binding; actin bindingBiological Process: lamellipodium biogenesis; axon guidance; organ morphogenesis; visual perception; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
