The ABLIM1 Polyclonal Antibody (PACO07536) is a key tool for researchers studying ABLIM1, a protein involved in actin binding and cytoskeleton organization. This antibody, produced in rabbits, shows high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By binding to the ABLIM1 protein, this antibody enables precise detection and analysis in various cell types, facilitating research in cell biology, cytoskeletal dynamics, and cancer metastasis.
ABLIM1 is known for its role in actin cytoskeleton organization and dynamics, essential for cellular processes such as cell migration, adhesion, and division. Dysregulation of ABLIM1 has been linked to cancer progression and metastasis, making it a promising target for therapeutic intervention. By understanding the function and regulation of ABLIM1, researchers can uncover new insights into cancer biology and potential treatment strategies targeting the cytoskeleton.
actin binding LIM protein 1;ABLIM1;ABLIM;DKFZp781D0148;FLJ14564;KIAA0059;LIMAB1;LIMATIN;MGC1224 ;
UniProt Protein Function:
abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-bindingChromosomal Location of Human Ortholog: 10q25Cellular Component: lamellipodium; cytoplasm; stress fiber; actin cytoskeletonMolecular Function: protein binding; zinc ion binding; actin bindingBiological Process: lamellipodium biogenesis; axon guidance; organ morphogenesis; visual perception; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
