The ABL1 Polyclonal Antibody (CAB0282) is a powerful tool for researchers studying ABL1, a key protein involved in cell signaling and regulation. This antibody, produced in rabbits, has high specificity and sensitivity for detecting ABL1 in human samples, making it a valuable asset for Western blot experiments.ABL1 is a proto-oncogene that plays a crucial role in growth and proliferation signaling pathways. Dysregulation of ABL1 has been linked to various cancers and other diseases, highlighting its importance as a therapeutic target.
By using the ABL1 Polyclonal Antibody, researchers can gain insights into the function and activity of ABL1 in different cell types and disease contexts, advancing our understanding of its role in cancer and other conditions.Overall, the ABL1 Polyclonal Antibody is a valuable tool for researchers investigating ABL1 biology and its implications for disease pathology and therapeutic development. Its high reactivity and specificity make it an ideal choice for studying ABL1 in a research setting.
Product Name:
ABL1 Rabbit Polyclonal Antibody
SKU:
CAB0282
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1130 of human c-Abl (NP_005148.2).
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Purification Method:
Affinity purification
Gene ID:
25
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using c-Abl Rabbit pAb (CAB0282) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
