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ABL1/ABL2 Antibody (PACO03759)

SKU:
PACO03759
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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ABL1/ABL2 Antibody (PACO03759)

The ABL1/ABL2 Antibody (PAC03759) is a high-quality polyclonal antibody designed for research involving the ABL1 and ABL2 proteins, which are important regulators of cell growth, differentiation, and response to DNA damage. This antibody is raised in rabbits and is highly reactive with human samples, making it suitable for use in Western blot and immunofluorescence applications.The ABL1/ABL2 Antibody specifically binds to the ABL1 and ABL2 proteins, allowing for precise detection and analysis in various cell types. These proteins play a crucial role in signal transduction pathways that control cell proliferation and survival, making them essential targets for research in oncology and developmental biology.

By studying the function and expression of ABL1 and ABL2, researchers can gain valuable insights into the mechanisms underlying cancer development, drug resistance, and other cellular processes. The ABL1/ABL2 Antibody offers a reliable tool for investigating the role of these proteins in disease progression and potential therapeutic interventions.

Antibody Name:ABL1/ABL2 Antibody
Antibody SKU:PACO03759
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human Abl1/2 around the non-phosphorylation site of Y393/439.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
UniProt Protein Function:Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
NCBI Summary:This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
UniProt Code:P00519
NCBI GenInfo Identifier:85681908
NCBI Gene ID:25
NCBI Accession:P00519.4
UniProt Secondary Accession:P00519,Q13869, Q13870, Q16133, Q17R61, Q45F09, A3KFJ3
UniProt Related Accession:P00519
Molecular Weight:124,955 Da
NCBI Full Name:Tyrosine-protein kinase ABL1
NCBI Synonym Full Names:ABL proto-oncogene 1, non-receptor tyrosine kinase
NCBI Official Symbol:ABL1  
NCBI Official Synonym Symbols:ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl  
NCBI Protein Information:tyrosine-protein kinase ABL1
UniProt Protein Name:Tyrosine-protein kinase ABL1
UniProt Synonym Protein Names:Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
Protein Family:Tyrosine-protein kinase
UniProt Gene Name:ABL1  
UniProt Entry Name:ABL1_HUMAN

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