The ABI1 Polyclonal Antibody (CAB16092) is a valuable tool for research involving ABI1, a protein implicated in cell signaling and cytoskeletal regulation. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to ABI1, this antibody enables researchers to study the protein's expression and function in various cell types, making it ideal for investigations related to cell biology and cancer research.ABI1 is known for its role in regulating actin dynamics and cell migration, making it a key player in processes like cell adhesion and axon guidance.
Dysregulation of ABI1 has been linked to diseases such as cancer, where abnormal cell migration and invasion are hallmark features. Understanding the function and regulation of ABI1 is crucial for unraveling its involvement in disease pathogenesis and potentially identifying new therapeutic targets. The ABI1 Polyclonal Antibody provides researchers with a reliable tool to explore the complexities of ABI1 biology and its implications in various physiological and pathological contexts.
Product Name:
ABI1 Rabbit Polyclonal Antibody
SKU:
CAB16092
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-230 of human ABI1 (NP_001012770).
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Purification Method:
Affinity purification
Gene ID:
10006
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain , using ABI1 Rabbit pAb (CAB16092) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
