ABCG8 Rabbit Polyclonal Antibody (CAB1880)
- SKU:
- CAB1880
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ABCG8 Rabbit Polyclonal Antibody |
SKU: | CAB1880 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human ABCG8 (NP_071882.1). |
Sequence: | MAGK AAEE RGLP KGAT PQDT SGLQ DRLF SSES DNSL YFTY SGQP NTLE VRDL NYQV DLAS QVPW FEQL AQFK MPWT SPSC QNSC ELGI QNLS FKVR SGQM LAII GSSG CGRA SLLD VITG RGHG GKIK SGQI WING QPSS PQLV RKCV AHVR QHNQ LLPN LTVR ETLA FIAQ MRLP RTFS QAQR DKRV EDVI AELR LRQC ADTR VGNM YVRG LSGG ERRR VSIG VQLL WNPG ILIL DEPT SGLD SFTA HNLV KTLS RLAK GNRL VLIS LHQP RSDI FRLF DLVL LMTS GTPI YLGA AQHM VQYF TAIG YPCP RYSN PADF |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | GBD4; STSL; STSL1; ABCG8 |
Positive Sample: | Rat uterus,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 76kDa |
Observed MW: | 76kDa |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.
Purification Method: | Affinity purification |
Gene ID: | 64241 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |