The ABCG8 Polyclonal Antibody (CAB1880) is a cutting-edge tool for researchers studying the ABCG8 protein, a crucial member of the ATP-binding cassette (ABC) transporter family. This antibody, produced through immunization of rabbits, exhibits high specificity and reactivity with human samples, making it an indispensable tool for Western blot applications.ABCG8 is primarily involved in the transport of cholesterol and other sterols across cell membranes, playing a key role in cholesterol regulation and homeostasis. Dysregulation of ABCG8 has been linked to various metabolic disorders, including hypercholesterolemia and gallstone formation.
The ABCG8 Polyclonal Antibody allows for precise detection and analysis of ABCG8 expression in a variety of cell types, offering valuable insights into cholesterol metabolism and related diseases.With its unique ability to target ABCG8, this antibody is an essential resource for researchers investigating lipid metabolism, cardiovascular health, and the molecular mechanisms underlying cholesterol-related pathologies. By enabling the study of ABCG8 expression and function, this antibody contributes to a deeper understanding of disease mechanisms and the development of potential therapeutic interventions.
Product Name:
ABCG8 Rabbit Polyclonal Antibody
SKU:
CAB1880
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human ABCG8 (NP_071882.1).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.
Purification Method:
Affinity purification
Gene ID:
64241
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ABCG8 Rabbit pAb (CAB1880) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
