ABCG2 Rabbit Monoclonal Antibody (CAB17908)
- SKU:
- CAB17908
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | ABCG2 Rabbit Monoclonal Antibody |
SKU: | CAB17908 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABCG2 (Q9UNQ0). |
Sequence: | SGLS GDVL INGA PRPA NFKC NSGY VVQD DVVM GTLT VREN LQFS AALR LATT MTNH EKNE RINR VIQE LGLD KVAD SKVG TQFI RGVS GGER KRTS IGME L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; CDw388; UAQTL1; EST157481; ABCG2 |
Positive Sample: | A549,HepG2,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Mitochondrion membrane, Multi-pass membrane protein. |
Calculated MW: | 72kDa |
Observed MW: | 72kDa |
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9429 |
Clone Number: | ARC0383 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |