The ABCE1 Rabbit Monoclonal Antibody (CAB9135) is a valuable tool for researchers studying ABCE1, a protein essential for ribosome biogenesis and translation initiation. This antibody, generated from rabbit immunizations, is highly specific to human ABCE1 and has been validated for use in various applications, including Western blot and immunofluorescence. It binds specifically to ABCE1, allowing for precise detection and analysis in a variety of cell types.
ABCE1 is a crucial factor in the translation process and has been linked to various diseases, including cancer and neurodegenerative disorders. By targeting ABCE1 with this antibody, researchers can gain valuable insights into its function and potential therapeutic applications. This antibody is a valuable asset for studies in molecular biology, cell biology, and disease mechanisms related to ABCE1.
Product Name:
ABCE1 Rabbit Monoclonal Antibody
SKU:
CAB9135
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-599 of human ABCE1 ( NP_002931.2).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6059
Clone Number:
ARC1445
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ABCE1 Rabbit mAb (CAB9135) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
