The ABCD3 Polyclonal Antibody (CAB18177) is a valuable tool for researchers studying the ABCD3 protein, which plays a crucial role in peroxisomal fatty acid beta-oxidation. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the ABCD3 protein, this antibody enables accurate detection and analysis in various cell types, allowing for in-depth investigations into peroxisomal function and lipid metabolism.The ABCD3 protein is essential for the transport of long-chain fatty acids into the peroxisome for breakdown, making it a key player in energy production and lipid metabolism. Dysregulation of ABCD3 has been linked to disorders such as Zellweger syndrome and X-linked adrenoleukodystrophy, highlighting its importance in human health.
Research on ABCD3 is not only relevant for understanding these rare genetic conditions but also for exploring potential therapeutic targets in metabolic disorders and neurodegenerative diseases.Overall, the ABCD3 Polyclonal Antibody (CAB18177) is a valuable tool for researchers investigating peroxisomal function, lipid metabolism, and the role of ABCD3 in health and disease. Its high specificity and reactivity make it a reliable choice for Western blot experiments, providing essential insights into the function and regulation of the ABCD3 protein.
Product Name:
PMP70/ABCD3 Rabbit Polyclonal Antibody
SKU:
CAB18177
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 340-475 of human PMP70/ABCD3 (NP_002849.1).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
5825
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PMP70/ABCD3 Rabbit pAb (CAB18177) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
