The ABCD2 Polyclonal Antibody (CAB16033) is a valuable tool for researchers studying the ABCD2 protein, a key player in peroxisomal fatty acid beta-oxidation and implicated in various metabolic disorders. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.ABCD2 is crucial for the transport of long-chain fatty acids into peroxisomes for degradation, making it essential for lipid metabolism and energy production. Dysregulation of ABCD2 has been linked to disorders such as Zellweger syndrome and X-linked adrenoleukodystrophy, highlighting its importance in maintaining cellular homeostasis.
By specifically detecting and binding to the ABCD2 protein, this antibody enables researchers to study its expression and function in different cell types and tissues, allowing insights into the mechanisms underlying metabolic diseases. Overall, the ABCD2 Polyclonal Antibody is a valuable tool for advancing our understanding of lipid metabolism and related disorders.
Product Name:
ABCD2 Rabbit Polyclonal Antibody
SKU:
CAB16033
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
Purification Method:
Affinity purification
Gene ID:
225
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of L929 cells using ABCD2 Rabbit pAb (CAB16033) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
