The ABCC6 Polyclonal Antibody (CAB8100) is a valuable tool for researchers studying the ABCC6 protein, which is involved in the transport of substrates across cell membranes and plays a crucial role in various physiological processes. The antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the ABCC6 protein, allowing for accurate detection and analysis in a variety of cell types.ABCC6 has been implicated in the development of certain diseases, particularly those related to abnormal mineralization and calcification of tissues.
Research into the function and regulation of ABCC6 is essential for understanding its role in these pathological processes, including conditions such as pseudoxanthoma elasticum. By elucidating the mechanisms by which ABCC6 influences disease development, scientists can pave the way for the development of novel therapeutic interventions targeting this protein.
Product Name:
ABCC6 Rabbit Polyclonal Antibody
SKU:
CAB8100
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
368
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ABCC6 antibody (CAB8100) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
