The ABCC4 Polyclonal Antibody (CAB2198) is a powerful tool for researchers studying the ABCC4 protein, also known as multidrug resistance-associated protein 4 (MRP4). This cell surface transporter is involved in the efflux of various endogenous and xenobiotic substrates, playing a key role in drug resistance mechanisms.Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the ABCC4 protein, allowing for accurate detection and analysis in a variety of cell types.
This makes it an essential component for studies in pharmacology, toxicology, and cancer research.Understanding the function of ABCC4 is essential for developing effective treatments for diseases characterized by drug resistance, such as cancer. By targeting this transporter, researchers can potentially overcome resistance mechanisms and enhance the efficacy of chemotherapy drugs. The ABCC4 Polyclonal Antibody is a valuable tool for unraveling the complex biology of this protein and exploring its potential as a therapeutic target.
Product Name:
MRP4/ABCC4 Rabbit Polyclonal Antibody
SKU:
CAB2198
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1067-1325 of human MRP4/ABCC4 (NP_005836.2).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10257
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using MRP4/ABCC4 Rabbit pAb (CAB2198) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
