ABCB9 Antibody (PACO49334)
- SKU:
- PACO49334
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
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Frequently bought together:
Description
ABCB9 Antibody (PACO49334)
The ABCB9 Polyclonal Antibody (PAC049334) is a powerful tool for researchers studying ABCB9, a key protein involved in cellular transport and ion homeostasis. This antibody, generated in rabbits, is specifically designed for use in immunohistochemistry and immunofluorescence applications, allowing for precise localization and visualization of ABCB9 in various tissues and cell types.ABCB9, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the efflux of various molecules across cellular membranes, contributing to drug resistance and cellular detoxification processes.
Its involvement in cellular transport dynamics makes it a promising target for investigating drug resistance mechanisms in cancer cells and other diseases.The ABCB9 Polyclonal Antibody is highly sensitive and specific, enabling researchers to accurately assess ABCB9 expression levels and subcellular localization in experimental models. By elucidating the function and regulation of ABCB9, researchers can gain insights into its role in cellular physiology and potentially identify new therapeutic targets for drug-resistant cancers and other conditions.
| Antibody Name: | ABCB9 Antibody (PACO49334) |
| Antibody SKU: | PACO49334 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human ATP-binding cassette sub-family B member 9 protein (630-766AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HL60 whole cell lysate, Mouse brain tissue, Mouse heart tissue, Mouse kidney tissue. All lanes: ABCB9 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 85, 80, 67, 76, 78 kDa. Observed band size: 85 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO49334 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. |
| Synonyms: | ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL), ABCB9, KIAA1520 |
| UniProt Protein Function: | ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 12q24Cellular Component: lysosomal membrane; lysosome; endoplasmic reticulum; early endosome; integral to membrane; integral to endoplasmic reticulum membraneMolecular Function: protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity; ATP binding; peptide-transporting ATPase activityBiological Process: peptide transport; antigen processing and presentation of peptide antigen via MHC class I; protein transport; metabolic process; transmembrane transport |
| UniProt Protein Details: | |
| NCBI Summary: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q9NP78 |
| NCBI GenInfo Identifier: | 22095458 |
| NCBI Gene ID: | 23457 |
| NCBI Accession: | Q9NP78.1 |
| UniProt Secondary Accession: | Q9NP78 |
| UniProt Related Accession: | Q9NP78 |
| Molecular Weight: | 84kDa |
| NCBI Full Name: | ATP-binding cassette sub-family B member 9 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily B member 9 |
| NCBI Official Symbol: | ABCB9Â Â |
| NCBI Official Synonym Symbols: | TAPL; EST122234Â Â |
| NCBI Protein Information: | ATP-binding cassette sub-family B member 9 |
| UniProt Protein Name: | ATP-binding cassette sub-family B member 9 |
| UniProt Synonym Protein Names: | ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL |
| Protein Family: | ABC transporter B family |
| UniProt Gene Name: | ABCB9Â Â |
| UniProt Entry Name: | ABCB9_HUMAN |
| Antibodies | ELISA Kits |
| ABCB9 Antibody (PACO07521) | Human ATP-binding cassette sub-family B member 9 (ABCB9) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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