ABCB9 Antibody (PACO17474)
- SKU:
- PACO17474
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ABCB9 Antibody (PACO17474)
The ABCB9 Antibody (PAC017474) is a high-quality polyclonal antibody designed for research involving ABCB9, a critical transporter protein involved in cellular detoxification and drug resistance mechanisms. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.ABCB9, also known as ATP-binding cassette sub-family B member 9, plays a crucial role in transporting a wide range of substrates out of cells, including drugs and toxins. Its function in cellular detoxification and drug resistance makes it a compelling target for research in drug development, cancer biology, and pharmacology.
Understanding the mechanisms of ABCB9 can enhance our knowledge of drug resistance in cancer cells and pave the way for developing more effective treatment strategies.Overall, the ABCB9 Antibody (PAC017474) is a valuable tool for studying the function and expression of ABCB9 in different cell types and tissues. Its specificity and reliability make it an ideal choice for researchers interested in unraveling the complex roles of ABC transporters in cellular physiology and disease.
| Antibody Name: | ABCB9 Antibody (PACO17474) |
| Antibody SKU: | PACO17474 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ABCB9 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17474(ABCB9 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO17474(ABCB9 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO17474(ABCB9 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. |
| Synonyms: | ATP-binding cassette, sub-family B (MDR/TAP), member 9 |
| UniProt Protein Function: | ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 12q24Cellular Component: lysosomal membrane; lysosome; endoplasmic reticulum; early endosome; integral to membrane; integral to endoplasmic reticulum membraneMolecular Function: protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity; ATP binding; peptide-transporting ATPase activityBiological Process: peptide transport; antigen processing and presentation of peptide antigen via MHC class I; protein transport; metabolic process; transmembrane transport |
| UniProt Protein Details: | |
| NCBI Summary: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q9NP78 |
| NCBI GenInfo Identifier: | 22095458 |
| NCBI Gene ID: | 23457 |
| NCBI Accession: | Q9NP78.1 |
| UniProt Secondary Accession: | Q9NP78 |
| UniProt Related Accession: | Q9NP78 |
| Molecular Weight: | 84kDa |
| NCBI Full Name: | ATP-binding cassette sub-family B member 9 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily B member 9 |
| NCBI Official Symbol: | ABCB9Â Â |
| NCBI Official Synonym Symbols: | TAPL; EST122234Â Â |
| NCBI Protein Information: | ATP-binding cassette sub-family B member 9 |
| UniProt Protein Name: | ATP-binding cassette sub-family B member 9 |
| UniProt Synonym Protein Names: | ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL |
| Protein Family: | ABC transporter B family |
| UniProt Gene Name: | ABCB9Â Â |
| UniProt Entry Name: | ABCB9_HUMAN |
| Antibodies | ELISA Kits |
| ABCB9 Antibody (PACO07521) | Human ATP-binding cassette sub-family B member 9 (ABCB9) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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