The ABCB8 Polyclonal Antibody (CAB2653) is a vital tool for researchers studying ABCB8, a protein involved in mitochondrial function and energy production. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications. By binding to ABCB8, this antibody enables the detection and analysis of the protein in various cell types, facilitating research in the fields of metabolism, cell biology, and mitochondrial dysfunction.ABCB8, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in transporting molecules across mitochondrial membranes, impacting cellular energy production and metabolism.
Dysregulation of ABCB8 has been linked to various diseases, including mitochondrial disorders and heart disease, highlighting its importance in cellular homeostasis. Investigating the function and regulation of ABCB8 with this antibody can provide valuable insights into the mechanisms underlying these conditions and guide the development of potential therapeutic strategies.
Product Name:
ABCB8 Rabbit Polyclonal Antibody
SKU:
CAB2653
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 469-718 of human ABCB8 (NP_009119.2).
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11194
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ABCB8 Rabbit pAb (CAB2653) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
