The ABCB10 Polyclonal Antibody (CAB13787) is a vital tool for researchers studying the ABCB10 protein, which plays a crucial role in mitochondrial function and cellular energy metabolism. The antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By binding to the ABCB10 protein, this antibody allows for accurate detection and analysis in various cell types, facilitating investigations in fields such as bioenergetics, mitochondrial biology, and cardiovascular research.
ABCB10, a member of the ATP-binding cassette transporter family, is essential for maintaining mitochondrial iron homeostasis and heme biosynthesis, which are vital processes for cellular respiration and energy production. Dysregulation of ABCB10 has been implicated in various diseases, including mitochondrial disorders, cardiovascular diseases, and cancer. Therefore, studying the function and regulation of ABCB10 is crucial for advancing our understanding of these conditions and developing targeted therapeutic strategies to address them.
Product Name:
ABCB10 Rabbit Polyclonal Antibody
SKU:
CAB13787
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 230-300 of human ABCB10 (NP_036221.2).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown.
Purification Method:
Affinity purification
Gene ID:
23456
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ABCB10 Rabbit pAb (CAB13787) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
