The ABCA7 Polyclonal Antibody (CAB18280) is a valuable tool for researchers studying ABCA7, a protein involved in the transport of lipids and the regulation of immune responses. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples and is validated for use in Western blotting applications. By targeting the ABCA7 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for investigations in immunology and neurology research.ABCA7 has been linked to Alzheimer's disease, a neurodegenerative disorder characterized by the accumulation of amyloid plaques in the brain.
Research suggests that ABCA7 plays a critical role in the clearance of amyloid beta, a protein fragment associated with Alzheimer's pathology. Understanding the function of ABCA7 is crucial for developing targeted therapies aimed at interfering with amyloid beta accumulation and potentially halting the progression of Alzheimer's disease. By utilizing the ABCA7 Polyclonal Antibody (CAB18280), researchers can gain valuable insights into the role of ABCA7 in lipid metabolism and immune regulation, advancing our understanding of Alzheimer's disease and other related neurological conditions.
Product Name:
ABCA7 Rabbit Polyclonal Antibody
SKU:
CAB18280
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2010-2146 of human ABCA7 (NP_061985.2).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system.
Purification Method:
Affinity purification
Gene ID:
10347
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using ABCA7 Rabbit pAb (CAB18280) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
