The ABCA5 Polyclonal Antibody (PAC050862) is a valuable tool for research involving the ABCA5 protein, a member of the ATP-binding cassette (ABC) transporter family. ABCA5 is known to play a crucial role in lipid transport and homeostasis, making it a key player in various metabolic processes.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ABCA5 protein, researchers can accurately detect and analyze levels of ABCA5 in different cell types, making it an ideal choice for studies related to lipid metabolism, cholesterol transport, and drug resistance mechanisms.
The ABCA5 Polyclonal Antibody is essential for researchers interested in understanding the function and regulation of ABCA5 in various physiological and pathological conditions. With its high reactivity and specificity, this antibody provides reliable results, ultimately aiding in the development of therapeutic strategies targeting ABCA5-related pathways in diseases such as hypercholesterolemia, diabetes, and cancer.
Antibody Name:
ABCA5 Antibody (PACO50862)
Antibody SKU:
PACO50862
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human ATP-binding cassette sub-family A member 5 protein (1230-1355AA)
Immunohistochemistry of paraffin-embedded human liver cancer using PACO50862 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO50862 at dilution of 1:100.
Background:
May play a role in the processing of autolysosomes.
Synonyms:
ATP-binding cassette sub-family A member 5, ABCA5, KIAA1888
UniProt Protein Function:
ABCA5: May play a role in the processing of autolysosomes. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17q24.3Cellular Component: Golgi membrane; lysosome; late endosome membrane; lysosomal membrane; late endosome; integral to membraneMolecular Function: transporter activity; ATPase activity; ATP bindingBiological Process: reverse cholesterol transport; metabolic process; cholesterol efflux
UniProt Protein Details:
NCBI Summary:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
