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ABCA4 Rabbit Polyclonal Antibody (CAB10556)

SKU:
CAB10556
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-ABCA4 Antibody CAB10556
  • Signal Transduction Antibodies 1 Anti-ABCA4 Antibody CAB10556
€139 - €419
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Description

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ABCA4 Rabbit Polyclonal Antibody (CAB10556)

The ABCA4 Polyclonal Antibody (CAB10556) is a valuable tool for researchers conducting studies involving ABCA4, a cell membrane protein associated with the transport of lipids and retinal health. Developed through immunization of rabbits, this antibody exhibits high reactivity with human samples and has been validated for Western blot applications. By specifically binding to the ABCA4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for research in ophthalmology and lipid metabolism.

ABCA4 is a key player in maintaining the integrity of the retinal pigment epithelium and the visual cycle by facilitating the transport of retinoids. Dysregulation of ABCA4 function is linked to the development of retinal degenerative diseases, such as Stargardt disease and age-related macular degeneration. Investigating the role and function of ABCA4 is essential for understanding the pathophysiology of these conditions and developing potential therapeutic interventions to preserve vision and prevent vision loss.

Product Name:ABCA4 Rabbit Polyclonal Antibody
SKU:CAB10556
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-300 of human ABCA4 (NP_000341.2).
Sequence:QELL MNAP ESQH LGRI WTEL HILS QFMD TLRT HPER IAGR GIRI RDIL KDEE TLTL FLIK NIGL SDSV VYLL INSQ VRPE QFAH GVPD LALK DIAC SEAL LERF IIFS QRRG AKTV RYAL CSLS QGTL QWIE DTLY ANVD FFKL FRVL PTLL DSRS QGIN LRSW GGIL SDMS PRIQ EFIH RPSM QDLL WVT
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1; ABCA4
Positive Sample:Mouse eye
Conjugate:Unconjugated
Cellular Localization:Membrane, Multi-pass membrane protein.
Calculated MW:256kDa
Observed MW:256kDa

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, and the gene product mediates transport of an essental molecule, all-trans-retinal aldehyde (atRAL), across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Purification Method:Affinity purification
Gene ID:24
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse eye, using ABCA4 Rabbit pAb (CAB10556) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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