The ABCA2 Polyclonal Antibody (CAB16735) is a vital tool for researchers studying the ATP-binding cassette transporter 2 (ABCA2) protein. This antibody, produced in rabbits, exhibits high reactivity with human samples and is ideal for use in Western blot applications. By specifically binding to the ABCA2 protein, this antibody enables researchers to detect and analyze ABCA2 expression in various cell types, facilitating studies in neuroscience, lipid metabolism, and neurodegenerative diseases.ABCA2 is a membrane transporter protein that plays a crucial role in lipid transport and homeostasis in the brain. Dysregulation of ABCA2 has been linked to various neurodegenerative disorders, making it a promising therapeutic target for conditions such as Alzheimer's disease and multiple sclerosis.
Research on the functions and regulation of ABCA2 is essential for understanding its role in these diseases and developing potential treatments that target this protein.Overall, the ABCA2 Polyclonal Antibody (CAB16735) is a valuable resource for researchers interested in investigating the role of ABCA2 in brain health and disease. Its high specificity and reactivity with human samples make it a reliable tool for studying the functions and dysregulation of ABCA2 in various pathological conditions.
Product Name:
ABCA2 Rabbit Polyclonal Antibody
SKU:
CAB16735
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-350 of human ABCA2 (NP_001597.2).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
20
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ABCA2 Rabbit pAb (CAB16735) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
