The ABCA12 Polyclonal Antibody (CAB17680) is a valuable tool for researchers studying ABCA12, a member of the ATP-binding cassette (ABC) transporter family known to be involved in lipid transport and skin barrier function. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the ABCA12 protein, researchers can easily detect and analyze its expression in various cell types, making it an essential tool for studies in dermatology and lipid metabolism research.
ABCA12 plays a crucial role in maintaining the skin barrier and protecting against dehydration, making it a key player in skin health and conditions such as Harlequin ichthyosis, a severe genetic disorder characterized by thick, scaly skin. Understanding the function and regulation of ABCA12 is essential for developing therapeutic strategies for skin disorders and lipid metabolism-related diseases. The ABCA12 Polyclonal Antibody allows researchers to unravel the complexities of ABCA12 biology and its implications for skin health and disease.
Product Name:
ABCA12 Rabbit Polyclonal Antibody
SKU:
CAB17680
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2456-2595 of human ABCA12 (NP_775099.2).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
26154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH-3T3 cells using ABCA12 Rabbit pAb (CAB17680) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
