GABA transaminase (ABAT) Rabbit Monoclonal Antibody (CAB9146)
- SKU:
- CAB9146
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Neuroscience
Description
Product Name: | GABA transaminase (ABAT) Rabbit Monoclonal Antibody |
SKU: | CAB9146 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GABA transaminase (ABAT) (P80404). |
Sequence: | MASM LLAQ RLAC SFQH SYRL LVPG SRHI SQAA AKVD VEFD YDGP LMKT EVPG PRSQ ELMK QLNI IQNA EAVH FFCN YEES RGNY LVDV DGNR MLDL YSQI |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | GABAT; NPD009; GABA-AT; GABA transaminase (ABAT) |
Positive Sample: | HepG2,BxPC-3,SH-SY5Y,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 56kDa |
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 18 |
Clone Number: | ARC1450 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |