UniProt Protein Function: | Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.Protein type: Membrane protein, integral; EC 2.7.11.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr familyChromosomal Location of Human Ortholog: 17q25.3 |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
UniProt Code: | Q6ZMQ8 |
NCBI GenInfo Identifier: | 114149222 |
NCBI Gene ID: | 9625 |
NCBI Accession: | Q6ZMQ8.2 |
UniProt Secondary Accession: | Q6ZMQ8,O75136, Q6ZN31, Q86X28 |
UniProt Related Accession: | Q6ZMQ8 |
Molecular Weight: | 93,226 Da |
NCBI Full Name: | Serine/threonine-protein kinase LMTK1 |
NCBI Synonym Full Names: | apoptosis associated tyrosine kinase |
NCBI Official Symbol: | AATKÂ Â |
NCBI Official Synonym Symbols: | LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77Â Â |
NCBI Protein Information: | serine/threonine-protein kinase LMTK1 |
UniProt Protein Name: | Serine/threonine-protein kinase LMTK1 |
UniProt Synonym Protein Names: | Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | AATKÂ Â |
UniProt Entry Name: | LMTK1_HUMAN |