The AATK Polyclonal Antibody (PAC017473) is a valuable tool for research involving AATK, a protein kinase involved in various cellular processes, including regulating cell growth and differentiation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the AATK protein, allowing for accurate detection and analysis in different cell types, making it an essential tool for studies in cell biology and signal transduction pathways.AATK, also known as apoptosis-associated tyrosine kinase, is a key player in controlling cell survival and death processes.
Its role in regulating cell fate makes it a promising target for research in cancer biology, neurodegenerative diseases, and developmental biology. Investigating the functions of AATK can provide valuable insights into disease mechanisms and potentially lead to the development of novel therapeutic strategies targeting this kinase.Overall, the AATK Polyclonal Antibody is a reliable reagent for researchers studying AATK and its role in cellular processes. Its high specificity and sensitivity make it a valuable tool for advancing our understanding of AATK function and its implications in various disease contexts.
Antibody Name:
AATK Antibody (PACO17473)
Antibody SKU:
PACO17473
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human AATK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17473(AATK Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17473(AATK Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
Apoptosis-associated tyrosine kinase
UniProt Protein Function:
Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.Protein type: Membrane protein, integral; EC 2.7.11.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr familyChromosomal Location of Human Ortholog: 17q25.3
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
