The AATK Polyclonal Antibody (PAC017472) is a valuable tool for researchers studying the AATK protein, a key player in neuronal development and synaptic plasticity. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the AATK protein, this antibody allows for the detection and analysis of AATK expression in various cell types, facilitating detailed research in neuroscience and brain-related disorders.AATK, also known as apoptosis-associated tyrosine kinase, is crucial for promoting neuronal survival and regulating synaptic function. Dysregulation of AATK has been implicated in neurodevelopmental disorders, neurodegenerative diseases, and psychiatric conditions.
By studying the role of AATK in these contexts, researchers can gain insights into potential therapeutic targets for treating neurological disorders and cognitive impairments.In conclusion, the AATK Polyclonal Antibody (PAC017472) offers a reliable solution for investigating the function and expression of the AATK protein in research settings focused on neuroscience, neurology, and psychiatric disorders. Its specificity and versatility make it a valuable tool for advancing our understanding of neuronal development and synaptic connectivity, ultimately paving the way for novel therapeutic interventions in the field of neurobiology.
Antibody Name:
AATK Antibody (PACO17472)
Antibody SKU:
PACO17472
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human AATK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO17472(AATK Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17472(AATK Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
Apoptosis-associated tyrosine kinase
UniProt Protein Function:
Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.Protein type: Membrane protein, integral; EC 2.7.11.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr familyChromosomal Location of Human Ortholog: 17q25.3
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
