The AARSD1 Polyclonal Antibody (PACO00350) is a valuable tool for researchers studying AARSD1, a protein involved in mitochondrial function and disease. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the AARSD1 protein, this antibody allows for the detection and analysis of AARSD1 in various cell types, making it ideal for studies in mitochondrial biology and genetic disorders.
AARSD1, also known as alanyl-tRNA synthetase (mitochondrial), plays a critical role in protein synthesis within mitochondria, the powerhouses of the cell. Dysregulation of AARSD1 has been linked to various mitochondrial diseases and disorders, making it a promising target for therapeutic interventions. Research into the function of AARSD1 is vital for advancing our understanding of mitochondrial biology and developing treatments for mitochondrial-related conditions.
Antibody Name:
AARSD1 Antibody
Antibody SKU:
PACO00350
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human AARSD1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
AARSD1; Alanyl-tRNA editing protein Aarsd1; Alanyl-tRNA synthetase domain-containing protein 1
UniProt Protein Function:
AARSD1: Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: LigaseChromosomal Location of Human Ortholog: 17q21.31Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; nucleic acid binding; metal ion binding; ATP binding; alanine-tRNA ligase activityBiological Process: regulation of translational fidelity; alanyl-tRNA aminoacylation
UniProt Protein Details:
NCBI Summary:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
