The AARS2 Polyclonal Antibody (CAB7826) is a valuable tool for research involving AARS2, a crucial enzyme involved in protein synthesis. This antibody, produced in rabbits, is highly specific to human AARS2 samples and has been validated for use in Western blot applications. By binding to the AARS2 protein, this antibody enables researchers to detect and analyze AARS2 in various cell types, making it an ideal choice for studies in molecular biology and genetic disorders.AARS2 plays a vital role in the translation of genetic information into proteins, making it essential for normal cell function and growth. Mutations in the AARS2 gene have been associated with various disorders, including Charcot-Marie-Tooth disease and other neurological conditions.
Understanding the function and regulation of AARS2 is critical for advancing research into these genetic disorders and identifying potential therapeutic targets.Overall, the AARS2 Polyclonal Antibody (CAB7826) is a valuable reagent for researchers studying protein synthesis, genetic diseases, and cellular pathways that rely on AARS2. Its high specificity and reliability make it an essential tool for advancing our understanding of the role of AARS2 in health and disease.
Product Name:
AARS2 Rabbit Polyclonal Antibody
SKU:
CAB7826
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 841-985 of human AARS2 (NP_065796.1).
Sequence:
RREL LATV KMLQ RRAN TAIR KLQM GQAA KKTQ ELLE RHSK GPLI VDTV SAES LSVL VKVV RQLC EQAP STSV LLLS PQPM GKVL CACQ VAQG AMPT FTAE AWAL AVCS HMGG KAWG SRVV AQGT GSTT DLEA ALSI AQTY ALSQ L
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
AARSL; LKENP; COXPD8; MTALARS; MT-ALARS; AARS2
Positive Sample:
HepG2,SKOV3,U-251MG,MCF7
Conjugate:
Unconjugated
Cellular Localization:
Mitochondrion.
Calculated MW:
107kDa
Observed MW:
107kDa
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
Purification Method:
Affinity purification
Gene ID:
57505
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AARS2 antibody (CAB7826) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
