The AARS Polyclonal Antibody (CAB7864) is a valuable tool for researchers studying AARS, an essential enzyme involved in protein synthesis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the AARS protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in molecular biology and cell biology.AARS, also known as alanyl-tRNA synthetase, plays a crucial role in the translation of genetic information into proteins.
Dysregulation of AARS activity has been linked to various diseases, including neurodegenerative disorders and cancer. By studying the function and regulation of AARS, researchers can gain insights into disease mechanisms and potential therapeutic targets. The AARS Polyclonal Antibody is a valuable tool for exploring the role of AARS in cellular processes and disease pathology.
Product Name:
AARS Rabbit Polyclonal Antibody
SKU:
CAB7864
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AARS (P49588).
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Purification Method:
Affinity purification
Gene ID:
16
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AARS antibody (CAB7864) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
