The AARS Polyclonal Antibody (CAB15017) is a valuable tool for researchers studying the AARS protein, a vital component of protein synthesis processes in cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the AARS protein, this antibody enables researchers to detect and analyze AARS expression in various cell types, making it an ideal choice for studies in molecular biology and biochemistry.AARS, also known as alanyl-tRNA synthetase, plays a crucial role in protein synthesis by catalyzing the attachment of alanine to transfer RNA molecules.
Dysregulation of AARS function has been implicated in various diseases, including neurological disorders and certain types of cancer. Understanding the role of AARS in cellular processes is essential for furthering our knowledge of these conditions and potentially identifying new therapeutic targets.By utilizing the AARS Polyclonal Antibody (CAB15017), researchers can gain valuable insights into the function and regulation of the AARS protein, paving the way for advancements in the fields of molecular biology and biomedicine.
Product Name:
AARS Rabbit Polyclonal Antibody
SKU:
CAB15017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AARS (NP_001596.2).
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Purification Method:
Affinity purification
Gene ID:
16
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AARS Rabbit pAb (CAB15017) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
