AANAT Rabbit Polyclonal Antibody (CAB11850)
- SKU:
- CAB11850
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | AANAT Rabbit Polyclonal Antibody |
SKU: | CAB11850 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human AANAT (NP_001079.1). |
Sequence: | MSTQ STHP LKPE APRL PPGI PESP SCQR RHTL PASE FRCL TPED AVSA FEIE REAF ISVL GVCP LYLD EIRH FLTL CPEL SLGW FEEG CLVA FIIG SLWD KERL MQES LTLH RSGG HIAH LHVL AVHR AFRQ QGRG PILL WRYL HHLG SQPA VRRA ALMC EDAL VPFY ERFS FHAV GPCA ITVG SLTF MELH CSLR GHPF LRRN SGC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DSPS; SNAT; AANAT |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 23kDa |
Observed MW: | 35kDa |
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 15 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |