AAK1 Antibody (PACO00349)
- SKU:
- PACO00349
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
AAK1 Antibody (PACO00349)
The AAK1 Polyclonal Antibody (PACO00349) is a valuable tool for researchers studying the AAK1 protein, a key regulator of endocytosis and signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to AAK1, researchers are able to detect and analyze this important protein in various cell types, making it ideal for investigations in areas such as cell biology and neuroscience.
AAK1, also known as AP2-associated protein kinase 1, plays a crucial role in the internalization of cell surface receptors and the regulation of various cellular processes. Dysregulation of AAK1 has been linked to diseases such as cancer, neurodegenerative disorders, and infectious diseases, highlighting its potential as a therapeutic target. Understanding the function of AAK1 is essential for developing treatments that target these diseases and improve patient outcomes.
| Antibody Name: | AAK1 Antibody |
| Antibody SKU: | PACO00349 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human AAK1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | AAK1; KIAA1048; AP2-associated protein kinase 1; Adaptor-associated kinase 1 |
| UniProt Protein Function: | AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Other group; NAK family Chromosomal Location of Human Ortholog: 2p14 Cellular Component: clathrin-coated vesicle; cytoplasm; extrinsic to plasma membrane; leading edge; terminal button Molecular Function:Notch binding; protein binding; protein serine/threonine kinase activity Biological Process: positive regulation of Notch signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of protein localization |
| NCBI Summary: | Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q2M2I8 |
| NCBI GenInfo Identifier: | 300669613 |
| NCBI Gene ID: | 22848 |
| NCBI Accession: | Q2M2I8.3 |
| UniProt Secondary Accession: | Q2M2I8,Q4ZFZ3, Q53RX6, Q9UPV4, |
| UniProt Related Accession: | Q2M2I8 |
| Molecular Weight: | 93,578 Da |
| NCBI Full Name: | AP2-associated protein kinase 1 |
| NCBI Synonym Full Names: | AP2 associated kinase 1 |
| NCBI Official Symbol: | AAK1Â Â |
| NCBI Protein Information: | AP2-associated protein kinase 1 |
| UniProt Protein Name: | AP2-associated protein kinase 1 |
| UniProt Synonym Protein Names: | Adaptor-associated kinase 1 |
| Protein Family: | AP2-associated protein kinase |
| UniProt Gene Name: | AAK1Â Â |
| UniProt Entry Name: | AAK1_HUMAN |
Related Products
AAK1 Antibody (PACO23021)
AAK1 Antibody (PACO21868)
AAK1 Antibody (PACO48618)
AAK1 Polyclonal Antibody (CAB22105)
AAK1 Colorimetric Cell-Based ELISA
Human AAK1 (AP2-associated protein kinase 1) ELISA Kit (HUFI05483)
