The AADAT Polyclonal Antibody (CAB13089) is a valuable tool for researchers studying AADAT, a key enzyme involved in metabolism and neurotransmitter regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting AADAT in human samples, making it suitable for applications such as Western blotting.AADAT, also known as aminoadipate aminotransferase, plays a vital role in the metabolism of lysine and tryptophan, as well as in the synthesis of kynurenic acid, a neuroactive metabolite.
Dysregulation of AADAT has been implicated in various diseases, including metabolic disorders and psychiatric conditions. Therefore, elucidating the function of AADAT is crucial for gaining insights into these pathological processes and developing potential therapeutic strategies.Overall, the AADAT Polyclonal Antibody is a valuable tool for researchers interested in studying the role of AADAT in health and disease, particularly in the fields of metabolism, neuroscience, and drug development.
Product Name:
AADAT Rabbit Polyclonal Antibody
SKU:
CAB13089
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 34-429 of human AADAT (NP_001273611.1).
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51166
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat kidney, using AADAT Rabbit pAb (CAB13089) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
