The AADACL2 Polyclonal Antibody (PAC015216) is a valuable tool for researchers studying AADACL2, an enzyme involved in lipid metabolism and inflammation regulation. This antibody, generated in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications. By binding to the AADACL2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for investigations in the fields of lipid biology and inflammatory disease research.AADACL2, also known as arylacetamide deacetylase-like 2, plays a crucial role in the breakdown of fatty acids and has been implicated in inflammatory pathways.
Its involvement in lipid metabolism and inflammation makes it a key target for research into diseases such as atherosclerosis, metabolic syndrome, and inflammatory disorders. Understanding the function of AADACL2 is essential for developing potential therapeutic interventions that target lipid metabolism and inflammatory processes.Overall, the AADACL2 Polyclonal Antibody (PAC015216) is a valuable resource for researchers looking to delve into the intricacies of AADACL2 biology and its implications for human health. Its high specificity and reliability in Western blot applications make it an indispensable tool for studies focused on lipid metabolism, inflammation, and related disease pathways.
Antibody Name:
AADACL2 Antibody (PACO15216)
Antibody SKU:
PACO15216
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human AADACL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15216(AADACL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15216(AADACL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
AADAC is a 45 kDa membrane-associated hydrolase highly expressed in the human liver that has been implicated in the hydrolysis of arylacetamide xenobiotics including flutamide and phenacetin.556–560AADAC is highly homologous to several related lipases, AADACL1, 2, and 4, the latter two of which remain completely unannotated. Overexpression of AADAC in a rat hepatoma cell line produces changes in cellular TG levels, apoplipoprotein B secretion, and fatty acid, oxidation, but the mechanism for these effects remains unclear.561 Candidate endogenous substrates, selective inhibitors, or knockout mice have not, to our knowledge, been described for AADAC or the related enzymes AADACL2 and AADACL4.
Synonyms:
arylacetamide deacetylase-like 2
UniProt Protein Function:
AADACL2: Belongs to the 'GDXG' lipolytic enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Hydrolase; Secreted; EC 3.1.1.-Chromosomal Location of Human Ortholog: 3q25.1
