The A2ML1 Polyclonal Antibody (CAB17831) is a valuable tool for researchers studying A2ML1, a protein involved in the regulation of protease activity and inflammation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the A2ML1 protein, researchers can effectively detect and analyze its expression in various cell types, making it an essential component for studies in immunology and cancer research.
A2ML1 is a key player in the regulation of protease activity, particularly in the inhibition of enzymes involved in inflammation and tissue degradation. Its role in modulating these processes makes it an intriguing target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of A2ML1 could lead to the development of novel therapies that target protease activity and inflammation in these diseases.
Product Name:
A2ML1 Rabbit Polyclonal Antibody
SKU:
CAB17831
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human A2ML1 (NP_653271.3).
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
144568
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using A2ML1 Rabbit pAb (CAB17831) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
