The A2M Polyclonal Antibody (CAB16336) is a valuable tool for researchers studying the alpha-2-macroglobulin (A2M) protein, a key player in the regulation of protease activity and inflammation. This antibody, produced in rabbits, is highly reactive with human samples, making it ideal for Western blot applications. By specifically binding to the A2M protein, this antibody enables precise detection and analysis in various cell types, facilitating in-depth investigations in the fields of immunology and cancer research.A2M is a multifunctional protein involved in various physiological processes, including the inhibition of proteases and the modulation of immune responses.
Its role in regulating inflammation and tissue remodeling makes it a promising target for studying a range of diseases, such as cancer, arthritis, and neurodegenerative disorders. Understanding the mechanisms of A2M can provide insights into disease progression and guide the development of novel therapeutic strategies aimed at manipulating immune responses and protease activity.
Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M)) (NP_000005.2).
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Purification Method:
Affinity purification
Gene ID:
2
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human placenta using Alpha-2-Macroglobulin (A2M) Rabbit pAb (CAB16336) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
