Alpha-2-Macroglobulin (A2M) Rabbit Polyclonal Antibody (CAB1573)
- SKU:
- CAB1573
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Alpha-2-Macroglobulin (A2M) Rabbit Polyclonal Antibody |
SKU: | CAB1573 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M)) (NP_000005.2). |
Sequence: | ALAG NQDK RKEV LKSL NEEA VKKD NSVH WERP QKPK APVG HFYE PQAP SAEV EMTS YVLL AYLT AQPA PTSE DLTS ATNI VKWI TKQQ NAQG GFSS TQDT VVAL HALS KYGA ATFT RTGK AAQV TIQS SGTF SSKF QVDN NNRL LLQQ VSLP ELPG EYSM KVTG EGCV YLQT SLKY NILP EKEE FPFA LGVQ TLPQ TCDE PKAH TSFQ ISLS VSYT GSRS ASNM AIVD VKMV SGFI PLKP TVKM LERS NHVS RTEV SSNH VLIY LDKV SNQT LSLF FTVL QDVP VRDL KPAI VKVY DYYE TDEF AIAE YNAP CSKD LGNA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M) |
Positive Sample: | Mouse uterus,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 163kDa |
Observed MW: | 163kDa |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Purification Method: | Affinity purification |
Gene ID: | 2 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |