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2'-O-methyladenosine/Am Rabbit Polyclonal Antibody (CAB2388)

SKU:
CAB2388
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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2'-O-methyladenosine/Am Rabbit Polyclonal Antibody (CAB2388)

The 2-O-Methyladenosine (AM) Polyclonal Antibody (CAB2388) is a valuable tool for researchers studying RNA modification. This rabbit polyclonal antibody is highly reactive with AM and is validated for use in various applications, including Western blot and immunofluorescence. It binds specifically to AM, allowing for the detection and analysis of this important RNA modification in different cellular contexts.AM is a modification found in RNA molecules that plays a crucial role in regulating gene expression and protein synthesis. Research indicates that dysregulation of RNA modifications, such as AM, is associated with various diseases, including cancer and neurological disorders.

By studying the role of AM in RNA biology, researchers can gain a better understanding of its functional significance and potential therapeutic implications.Overall, the 2-O-Methyladenosine (AM) Polyclonal Antibody (CAB2388) is a valuable tool for researchers interested in exploring the role of RNA modifications in gene regulation and disease pathogenesis. Its high specificity and reactivity make it an essential component for studies in molecular biology, biochemistry, and biomedical research.

Product Name:2'-O-methyladenosine/Am Rabbit Polyclonal Antibody
SKU:CAB2388
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Species independent
Immunogen:Chemical compounds corresponding to 2'-O-methyladenosine / Am.
Tested Applications:ELISA DB
Recommended Dilution:DB,1:500 - 1:2000
Synonyms:Am; 2'-O-methyladenosine; 2'-O-methyladenosine / Am

Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes. m6A is widely conserved among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs with a nuclear phase. The m6A-based modification is associated with a well-defined RNA motif, RRACH (R: A/G, H: A/C/U). As a representative of the epitranscriptome, m6A mRNA modifications participate in many vital activities in the cell, including stem cell self-renewal and differentiation, mRNA transcription, alternative splicing, nuclear export, translation, degradation, and microRNA processing. These processes determine the expression or inactivation of specific genes, which is vital for growth and development.(PMID: 30416848; PMID: 24662220; PMID: 30429466)

Purification Method:Affinity purification
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageThe 2'-O-methyladenosine / Am Rabbit pAb(CAB2388) are tested in Dot Blot against 2＇-O-methyladenosine (Am),N6,2＇-O-dimethyladenosine(m6Am),adenosine(A) and N6-methyladenosine(m6A).

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